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放射性心脏病的研究进展
于兰
万海涛
王刚
张小涛
作者及单位信息
·
DOI： 10.3760/cma.j.issn.0254-5098.2016.06.016
Research progress of radiation-induced heart disease
Yu Lan
Wan Haitao
Wang Gang
Zhang Xiaotao
Authors Info & Affiliations
Yu Lan
Department of Radiotherapy, The Second Affiliated Hospital of Qingdao University, Qingdao Central (Cancer) Hospital, Qingdao 266042, China
Wan Haitao
Department of Radiotherapy, The Second Affiliated Hospital of Qingdao University, Qingdao Central (Cancer) Hospital, Qingdao 266042, China
Wang Gang
Cancer Center, The Second Affiliated Hospital of Qingdao University, Qingdao Central (Cancer) Hospital, Qingdao 266042, China
Zhang Xiaotao
Cancer Prevention Center, The Second Affiliated Hospital of Qingdao University, Qingdao Central (Cancer) Hospital, Qingdao 266042, China
·
DOI： 10.3760/cma.j.issn.0254-5098.2016.06.016
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摘要

放射治疗是胸部肿瘤综合治疗的重要手段之一，在杀灭肿瘤的同时，放疗也可以造成放射性心脏病(radiation-induced heart disease，RIHD)，严重者影响患者生活质量，甚至危及生命。随着肿瘤综合治疗手段提高，患者生存时间延长，RIHD的临床研究报告日益增多，RIHD成为胸部肿瘤治疗的重要并发症。虽然现代放疗技术以及新的治疗原则的应用可降低RIHD的发生，其危害仍不容忽视。本文就RIHD的研究进展进行综述。

放射性心脏病;放射疗法;心脏损伤;影响因素
ABSTRACT

Radiation therapy is one of the important comprehensive treatment strategies for thoracic neoplasms, but it also can cause radiation-induced heart disease(RIHD) which can affect the quality of life and even endanger the lives of patients while killing tumor. With the development of comprehensive treatment for cancer, the patients achieve better survival outcomes. And the study reported about RIHD increased as well, which made RIHD became an important complication of thoracic neoplasms' treatment. Though modern radiotherapy techniques and new therapeutic principles have significantly made the incidence of RIHD decreased, the harm of RIHD should not be ignored. In this article, we review the research progress of RIHD.

Radiation-induced heart disease;Radiotherapy;Heart injuries;Risk factor
Zhang Xiaotao, Email: mocdef.6ab21djyjlz
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于兰,万海涛,王刚,等. 放射性心脏病的研究进展[J]. 中华放射医学与防护杂志,2016,36(6)：475-480.

DOI:10.3760/cma.j.issn.0254-5098.2016.06.016

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放射性心脏病(radiation-induced heart disease，RIHD)是胸部肿瘤放疗引起的一种严重不良反应，早期主要表现为急性心包炎，晚期表现为动脉粥样硬化、慢性心包炎、心肌病、心脏瓣膜损伤和心脏传导异常等 [ 1 ]。一旦发生，目前无法逆转，因此，研究RIHD的机制并提出预防策略具有重要的临床意义。本文就RIHD的病理学变化、发生机制、影响因素、预防措施以及筛查方式等方面进行综述，为预防和降低RIHD的发生提供临床指导性作用。
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备注信息
A
张小涛，Email: mocdef.6ab21djyjlz
B

于兰分析文献和撰写论文；万海涛、王刚收集文献和修改文章；张小涛拟定写作思路，指导文章的撰写和修改

C
本人与本人家属、其他研究者，未因进行该研究而接受任何不正当的职务或财务利益，在此对研究的独立性和科学性予以保证
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