AXIN2是重要的Wnt/β-catenin信号通路的调控因子，参与调控细胞增殖、细胞变异、细胞迁移、细胞凋亡和其他重要功能。现已证明 AXIN2基因与肝癌、结肠癌、肺癌、乳腺癌等的发展有密切关系。 AXIN2在肿瘤发生中的作用主要有三方面：① AXIN2甲基化和miRNA的调节可造成 AXIN2的异常表达(沉默或超表达)，导致肿瘤发生；②在Wnt通路、泛素依赖蛋白酶体通路和siRNA的调节下， AXIN2通过控制β-catenin降解而参与肿瘤的发生；③ AXIN2的变异可导致蛋白质异常表达和Wnt通路的失调，导致肿瘤发生。本文将对 AXIN2基因在肿瘤发生中的作用作一介绍。
AXIN2, a leading regulator in Wnt/β-catenin signaling pathway, participating in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the progression of liver cancer, colon cancer, breast cancer, lung cancer and so on. The function of AXIN2 in the tumorigenesis exists mainly in three ways. Firstly, AXIN2 methylation and the regulation of microRNA could induce tumorigenesis caused by the abnormal expression of AXIN2 (silencing or overexpression). Secondly, under the regulation of Wnt pathway, ubiquitin-dependent proteasome pathways and siRNA, AXIN2 participates in tumorigenesis by controlling the degradation of β-catenin. Thirdly, mutations of AXIN2 may cause the abnormal protein expression or the dysregulation of Wnt pathway, resulting in tumorigenesis. In this paper, the roles of AXIN2 in tumorigenesis will be reviewed.
殷琳,李东升,寇俊婕,等. AXIN2基因在肿瘤发生中的作用 [J]. 国际遗传学杂志,2016,39(2)：96-101.
DOI:10.3760/cma.j.issn.1673-4386.2016.02.008版权归中华医学会所有。
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