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ENGLISH ABSTRACT
首发广泛性焦虑障碍患者外周血炎性细胞因子与焦虑症状的相关性
叶刚
汤臻
李歆
潘明志
朱峰
付佳林
伏天
刘期春
高振勇
陈心韵
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1674-6554.2016.08.008
Correlation between peripheral inflammatory cytokines and anxiety symptoms in patients with the first-episode generalized anxiety disorder
Ye Gang
Tang Zhen
Li Xin
Pan Mingzhi
Zhu Feng
Fu Jialin
Fu Tian
Liu Qichun
Gao Zhenyong
Chen Xinyun
Authors Info & Affiliations
Ye Gang
Suzhou GuangJi Hospital, Suzhou 215000, China
Tang Zhen
Suzhou GuangJi Hospital, Suzhou 215000, China
Li Xin
School of Education of Soochow University, Suzhou 215000, China
Pan Mingzhi
Suzhou GuangJi Hospital, Suzhou 215000, China
Zhu Feng
Suzhou GuangJi Hospital, Suzhou 215000, China
Fu Jialin
Suzhou GuangJi Hospital, Suzhou 215000, China
Fu Tian
Suzhou GuangJi Hospital, Suzhou 215000, China
Liu Qichun
Suzhou GuangJi Hospital, Suzhou 215000, China
Gao Zhenyong
Suzhou GuangJi Hospital, Suzhou 215000, China
Chen Xinyun
School of Education of Soochow University, Suzhou 215000, China
·
DOI： 10.3760/cma.j.issn.1674-6554.2016.08.008
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摘要

目的探讨首发广泛性焦虑障碍患者外周血炎性细胞因子与焦虑症状的相关性。

方法运用夹心法酶联免疫吸附法(ELISA)技术测定48名首发广泛性焦虑障碍患者与48名对照组被试外周血IL-1、 IL-2、 IL-4、 IL-5、 IL-6、 IL-8、IL-10、 IL-12p70、GM-CSF、 IFN-γ水平，运用免疫透射比浊法测定C-反应蛋白(CRP)的血浓度，并应用广泛性焦虑障碍量表(GAD-7)、状态-特质焦虑问卷(STAI)评定其总体焦虑程度和特质焦虑、状态焦虑水平。

结果首发广泛性焦虑障碍组CRP[(1.19±0.80)mg/L vs (0.68±0.70)mg/L， t＝3.31]、IL-1α[(70.34±3.60)pg/ml vs (16.94±3.42)pg/ml， t＝74.50]、IL-2[(7.25±3.42)pg/ml vs (4.95±2.31)pg/ml， t＝3.85]、IL-4[(102.02±73.14)pg/ml vs (75.55±32.78)pg/ml， t＝2.29]、IL-6[(12.55±2.37)pg/ml vs (2.71±1.35)pg/ml， t＝14.79]、IL-8[(44.64±16.21)pg/ml vs (35.69±11.70)pg/ml， t＝3.10]、IL-12[(18.16±24.17)pg/ml vs (10.82±4.72)pg/ml， t＝2.06]、IFN-γ[(23.32±15.52) vs (16.48±6.80)pg/ml， t＝2.79]、GM-CSF[(19.07±11.12)pg/ml vs (13.40±8.54)pg/ml， t＝2.80]等炎性细胞因子水平显著高于正常对照组(均 P<0.05)；状态焦虑SAI、特质焦虑TAI与IL-1α、IL-2、IL-6、IL-8、IL-12、IFN-γ、GM-CSF均呈显著正相关，相关系数 r为0.24～0.76。

结论首发广泛性焦虑障碍患者外周血多个炎性细胞因子升高，并和总体焦虑程度、状态焦虑及特质焦虑水平呈正相关，提示其可能存在免疫功能异常。

广泛性焦虑障碍;特质焦虑;状态焦虑;炎性细胞因子
ABSTRACT

ObjectiveTo investigate the relationship between peripheral inflammatory cytokines and anxiety symptoms in patients with the first-episode generalized anxiety disorder.

Methods48 patients diagnosed with the first-episode generalized anxiety disorder according to ICD-10 criteria and 48 healthy subjects were recruited.Peripheral levels of IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, GM-CSF and IFN-γ of both groups were evaluated by enzyme-linked immunosorbent assay (ELISA), and CRP was evaluated by immunoturbidimetric method. Generalized Anxiety Disorder Scale(GAD-7) and State-Trait Anxiety Inventory(STAI)were used to assess the levels of overall anxiety, state anxiety and trait anxiety.

ResultsThe levels of CRP((1.19±0.80)mg/L vs (0.68±0.70)mg/L, t=3.31), IL-1α((70.34±3.60)pg/ml vs (16.94±3.42)pg/ml, t=74.50), IL-2((7.25±3.42)pg/ml vs (4.95±2.31)pg/ml, t=3.85), IL-4((102.02±73.14)pg/ml vs (75.55±32.78)pg/ml, t=2.29), IL-6((12.55±2.37)pg/ml vs (2.71±1.35)pg/ml, t=14.79), IL-8((44.64±16.21)pg/ml vs (35.69±11.70)pg/ml, t=3.10), IL-12((18.16±24.17)pg/ml vs (10.82±4.72)pg/ml, t=2.06), IFN-γ((23.32±15.52)pg/ml vs (16.48±6.80)pg/ml, t=2.79), GM-CSF((19.07±11.12)pg/ml vs (13.40±8.54)pg/ml, t=2.80) in patients with the first-episode generalized anxiety disorder were significantly higher than normal controls( P<0.05). Both SAI and TAI had significantly positive correlation with the levels of IL-1α, IL-2, IL-6, IL-8, IL-12, IFN-γ and GM-CSF( r=0.24-0.76, P<0.05).

ConclusionThe levels of some peripheral inflammatory cytokines in patients with the first-episode generalized anxiety disorder are significantly increased, and they have positive correlation with general anxiety, state anxiety and trait anxiety, which may suggest some immune system defects in the patients.

Generalized anxiety disorder;State anxiety;Trait anxiety;Inflammatory cytokines
Tang Zhen,Email: mocdef.labiamtohnehzt
Science and Technology Development Plans of Suzhou in 2014(SYSD2014132)
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叶刚,汤臻,李歆,等. 首发广泛性焦虑障碍患者外周血炎性细胞因子与焦虑症状的相关性[J]. 中华行为医学与脑科学杂志,2016,25(8)：709-712.

DOI:10.3760/cma.j.issn.1674-6554.2016.08.008

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广泛性焦虑障碍是严重影响人类健康的精神障碍之一，但其发病机制目前尚不明了，以往的研究多集中于神经递质的改变，近年来研究者开始关注炎症反应对广泛性焦虑障碍的作用。Oglodek等 [ 1 ]研究发现广泛性焦虑障碍的产生与免疫内环境的紊乱有关，通过免疫系统的激活导致免疫功能受损。有研究发现白细胞介素和炎性趋化性因子在广泛性焦虑障碍的免疫调节反应中扮演着重要角色 [ 2 , 3 ]。免疫激活产生的这些细胞因子在向大脑传输信号以产生神经化学、神经内分泌、神经免疫和行为改变的过程中起着重要作用 [ 4 ]。迄今为止，焦虑障碍与其免疫功能改变的心身交互作用机制及其因果关系尚不十分清楚，有关广泛性焦虑障碍患者免疫功能的研究结论也不一致 [ 5 ]。既往研究多集中于促炎性细胞因子，且往往仅从少数几个炎性细胞因子入手。本研究尝试同时从促炎性细胞因子与抗炎性细胞因子入手探索首发广泛性焦虑障碍患者多个炎性细胞因子特点，并分析不同焦虑维度(状态焦虑和特质焦虑)与炎性细胞因子的相关性，尝试探索炎性细胞因子是否可以作为鉴别具有不同特点的广泛性焦虑障碍患者的特征性指标。
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汤臻，Email： mocdef.labiamtohnehzt
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