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多西他赛的临床应用及其新剂型的研究进展
刘广宣
隋月
赵茜
刘嘉懿
作者及单位信息
·
DOI： 10.3760/cma.j.issn.1008-6706.2016.19.039
Advances in clinical research and new form of docetaxel
Liu Guangxuan
Sui Yue
Zhao Qian
Liu Jiayi
Authors Info & Affiliations
Liu Guangxuan
Department of Pharmacy Intravenous Admixture Service, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, China
Sui Yue
Department of Pharmacy Intravenous Admixture Service, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, China
Zhao Qian
Department of Pharmacy Intravenous Admixture Service, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, China
Liu Jiayi
Department of Pharmacy Intravenous Admixture Service, Liaoning Cancer Hospital, Shenyang, Liaoning 110042, China
·
DOI： 10.3760/cma.j.issn.1008-6706.2016.19.039
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摘要

多西他赛(docetaxel，DTX)是一种紫杉烷类抗肿瘤药，其抗瘤谱广，被广泛用于乳腺癌、肺癌、胃癌和前列腺癌等肿瘤的治疗。多西他赛不仅能够单独用药，也可与其他药物联用。近年来，多西他赛市售注射剂的毒副反应逐渐引起关注，为达到减效增毒的目的，新剂型的研究在如火如荼进行中。笔者对多西他赛的临床应用及新剂型开发进行了综述。

多西他赛;抗肿瘤;临床进展;新剂型
ABSTRACT

Docetaxel (DXT) is a member of the taxane drug class, which is used to treat breast cancer, lung cancer, gastric cancer, prostate cancer and so on.Docetaxel can be used as a single agent or in combination with other chemotherapeutic drugs.Many side effects of docetaxel have been reported in recent years.New dosage forms are developed to reduce toxicity and increase efficacy.An overview of these novel formulations of docetaxel and clinical progress will be discussed by consulting 43 literatures.

Docetaxel;Anticancer;Clinical progress;New dosage forms
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引用本文

刘广宣,隋月,赵茜,等. 多西他赛的临床应用及其新剂型的研究进展[J]. 中国基层医药,2016,23(19)：3029-3034.

DOI:10.3760/cma.j.issn.1008-6706.2016.19.039

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多西他赛是从欧洲红豆杉提取的非细胞毒性前体化合物10-脱酰基浆果赤霉素Ⅲ经半合成得到的紫杉烷类化合物，能够促进微管聚合，阻止微管解聚，阻滞细胞于G2和M期，从而抑制癌细胞的有丝分裂和增殖。多西他赛稳定微管作用比紫杉醇大2倍。法国Rhone-Poulenc Rorer公司为多西他赛原研厂家 [ 1 ]，1993年在国外申请专利，其产品泰索帝(Taxtotere，TXT)于1995年4月在墨西哥首次上市，1998年获美国食品药品监督管理局(FDA)批准，1996年进入我国临床。2002年我国医药公司通过避开工艺专利路线，获得"艾素"的新药批准，走上仿制之路，截止目前，国家食品药品监督管理总局(cFDA)已批准12家企业生产多西他赛原料药及10家企业生产注射剂。在国内的市场份额中，山东齐鲁制药的"多帕菲"、浙江万马药业的"斯曲帝"和江苏恒瑞的"艾素"三大品种以65%的份额占据主导地位，而泰索帝仅占据34.88%。随着国内外对多西他赛研究的深入，该产品已成为国内肿瘤临床常用药物之一，其注射剂已成功入选了2009版的《国家基本医疗保险和工伤保险药品目录》。
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