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肺静脉在肺动脉高压发病中的作用及其研究进展
吴雄婷
陈豫钦
卢文菊
王健
作者及单位信息
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DOI： 10.3760/cma.j.issn.1001-0939.2017.01.015
Role of pulmonary vein in pulmonary hypertension
Wu Xiongting
Chen Yuqin
Lu Wenju
Authors Info & Affiliations
Wu Xiongting
Chen Yuqin
Lu Wenju
·
DOI： 10.3760/cma.j.issn.1001-0939.2017.01.015
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摘要

肺动脉高压表现为肺循环血管压力和阻力进行性增加，并最终导致右心衰竭，其病理特征为远端肺动脉的异常收缩与重塑，包括肺动脉平滑肌和内皮细胞的异常增殖等。肺静脉是肺循环的重要组成部分，其结构功能改变直接影响肺循环血流动力学指标及肺换气功能。近年来肺静脉在肺动脉高压发病中的作用受到越来越多研究者的重视，研究结果表明慢性低氧不仅可以引起人肺小动脉重塑还能引起远端肺小静脉发生重塑，其病理改变为中膜增厚和内膜纤维化 [ 1 ] 。而且在低氧性肺动脉高压大鼠模型中出现远端肺静脉平滑肌发生增殖和迁移 [ 2 ] 。但目前肺静脉在肺动脉高压发病中的作用仍不清楚，进一步深入研究肺静脉在肺动脉高压发病中的作用，可以增加对疾病发病机制的认识，为临床诊治提供新的思路。

引用本文

吴雄婷,陈豫钦,卢文菊,等. 肺静脉在肺动脉高压发病中的作用及其研究进展[J]. 中华结核和呼吸杂志,2017,40(1)：68-70.

DOI:10.3760/cma.j.issn.1001-0939.2017.01.015

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肺动脉高压表现为肺循环血管压力和阻力进行性增加，并最终导致右心衰竭，其病理特征为远端肺动脉的异常收缩与重塑，包括肺动脉平滑肌和内皮细胞的异常增殖等。肺静脉是肺循环的重要组成部分，其结构功能改变直接影响肺循环血流动力学指标及肺换气功能。近年来肺静脉在肺动脉高压发病中的作用受到越来越多研究者的重视，研究结果表明慢性低氧不仅可以引起人肺小动脉重塑还能引起远端肺小静脉发生重塑，其病理改变为中膜增厚和内膜纤维化 [ 1 ]。而且在低氧性肺动脉高压大鼠模型中出现远端肺静脉平滑肌发生增殖和迁移 [ 2 ]。但目前肺静脉在肺动脉高压发病中的作用仍不清楚，进一步深入研究肺静脉在肺动脉高压发病中的作用，可以增加对疾病发病机制的认识，为临床诊治提供新的思路。
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备注信息
A
王健，Email： mocdef.oabohay6891gnawnaij
B
国家自然科学基金重大国际合作项目 (1220108001)
国家自然科学基金面上项目 (81470246)
广东省自然科学基金重点项目 (2016A030311020)
广东省自然科学基金-自由申请项目 (2016A030313606)
广州市卫生局医药卫生科技项目 (20151A011073)
广州市科学（技术）研究专项一般项目 (201607010358)
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