Review
Research progress on risk factors of monozygotic twins in assisted reproductive technology
Chen Na, Li Jingyu, Cui Linlin
Published 2023-02-25
Cite as Chin J Reprod Contracep, 2023, 43(2): 204-208. DOI: 10.3760/cma.j.cn101441-20210930-00445
Abstract
With the rapid development of assisted reproductive technology since the 1970s, the incidence of multiple pregnancies has increased significantly, and the maternal and infant complications during pregnancy and postpartum caused by multiple pregnancies have received extensive public attention. Relevant investigations showed that the rate of monozygotic twins after assisted reproductive technology was higher than that of natural pregnancy, which not only increase the risk of neonatal related adverse outcomes, but also has a far-reaching impact on the long-term health of offspring. In order to understand the related risk factors and potential mechanisms of monozygotic twins after assisted reproductive technology better and provide intervention target for reducing the rate of monozygotic twins in clinic, we sorted out papers about the rate of monozygotic twins in assisted reproductive technology offspring and the effects of factors such as ovulation induction, ovum and embryo manipulation, and in vitro culture on the incidence of monozygotic twins.
Key words:
Twins, monozygotic; Reproductive technology, assisted; Fertilization in vitro; Blastocyst transfer; Inner cell mass
Contributor Information
Chen Na
Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University
Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University
Shandong Key Laboratory of Reproductive Medicine
Shandong Provincial Clinical Research Center for Reproductive Health
National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China
Li Jingyu
Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University
Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University
Shandong Key Laboratory of Reproductive Medicine
Shandong Provincial Clinical Research Center for Reproductive Health
National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China
Cui Linlin
Center for Reproductive Medicine, the Second Hospital, Cheeloo College of Medicine, Shandong University
Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University
Shandong Key Laboratory of Reproductive Medicine
Shandong Provincial Clinical Research Center for Reproductive Health
National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China
