Review
Research progress on the effect of advanced maternal age on maternal psychology and neurobehavioral development of their offspring and related mechanisms
Liu Fang, Li Mengshi, Tian Tian, Fu Yu, Wang Xiaoli, Wang Yuanyuan, Qiao Jie
Published 2024-01-25
Cite as Chin J Reprod Contracep, 2024, 44(1): 77-82. DOI: 10.3760/cma.j.cn101441-20221111-00502
Abstract
With the changes in lifestyle, marriages and childbearing concepts, and population policies in recent years, the proportion of women with advanced maternal age (AMA) in China is rising rapidly. AMA and maternal stress due to advanced age are considered as independent risk factors for maternal mental health and the neurobehavioral development of their offspring. In this paper, we summarized how the glial cell line-derived neurotrophic factor, the hypothalamic-pituitary-adrenal axis, the 5-HT system and the oxytocin affect the maternal mental health and the neurobehavioral development of their offspring, as well as some potential targeted interventions. Interventions currently being developed include artificial supplements, antidepressants, physical exercise, nutrient supplementation, etc., but they have a limited efficacy and a high risk of side effects, yet there is still a lack of specific and systematic interventions. The relevant pathogenesis should continue to be explored in the future research, and hopefully more effective and safe interventions will be given in the near future to improve the mental health of mothers with AMA and the long-term healthy development of their offspring.
Key words:
Maternal age; Maternal health; Developmental disabilities; Neurobehavioral manifestations; Glial cell line-derived neurotrophic factor; Serotonin; Oxytocin; Hypothalamic-pituitary-adrenal axis
Contributor Information
Liu Fang
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)/Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
Li Mengshi
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China
Tian Tian
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)/Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
Fu Yu
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)/Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
Wang Xiaoli
Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China
Wang Yuanyuan
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)/Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
Qiao Jie
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital/National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)/Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China
