Regulation of energy metabolism by osteocalcin
Sheng Tong, Guo Xiangyu, Wang Xinxiang, Xie Peifeng, Shang Xuezheng, Zhou Hui, Guan Song
Published 2014-10-25
Cite as Chin J Endocrinol Metab, 2014,30(10): 862-864. DOI: 10.3760/cma.j.issn.1000-6699.2014.10.011
Abstract
Osteocalcin (OC) secreted by osteoblasts is a sensitive and specific indicator of osteoblast activity.Recently,it has been found that osteocalcin serves as an important mediator of endocrine function.Undercarboxylated OC can promote insulin secretion and β-cell proliferation,and lower glucose and lipid levels,suggesting that osteocalcin might play a major role in the regulation of energy metabolism.These findings provide a new insight for the treatment of metabolic diseases such as obesity and diabetes.
Key words:
Osteocalcin ; Osteoblasts ; Obesity
Contributor Information
Sheng Tong
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Guo Xiangyu
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Wang Xinxiang
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Xie Peifeng
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Shang Xuezheng
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Zhou Hui
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
Guan Song
Department of Endocrinology, Donfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China