Experimental Science
Mechanism of curcumin in the treatment of diabetic retinopathy based on network pharmacology and molecular docking
Du Yuanyuan, Wang Yiyun, Zhao Rong, Zhang Ji, Ji Xiaoyan, Lu Jiayu, Ji Fangfang, Lou Hui, Jiang Ziyuan, Huang Jiang
Published 2023-12-10
Cite as Chin J Exp Ophthalmol, 2023, 41(12): 1152-1159. DOI: 10.3760/cma.j.cn115989-20220314-00105
Abstract
ObjectiveTo investigate the mechanism of curcumin in the treatment of diabetic retinopathy (DR) by network pharmacology and molecular docking.
MethodsThe compounds targets of curcumin were predicted by SEA and SwissTargetPrediction databases, and the DR target genes were obtained by CTD database.The different genes were mapped and matched by Venny database to screen their intersections.The intersecting genes were submitted to GeneMANIA database to construct a protein-protein interaction network.WebGestalt database was used to conduct enrichment analysis and AutoDock Vina was used to perform molecular docking of the core targets.
ResultsA total of 52 targets of curcumin, 1 599 targets of DR and 48 intersecting targets were detected.The core targets were serine/threonine-protein kinase 1 (AKT1), tumor necrosis factor-α (TNF-α), epidermal growth factor receptor (EGFR), signal transduction and activator of transcription 3 (STAT3) and heat shock protein 90 alpha family class A member 1 (HSP90AA1). Enrichment analysis suggested that these targets were mainly associated with signaling pathways, including the EGFR tyrosine kinase inhibitor resistance signaling pathway, hypoxia-inducible factor-1 (HIF-1) signaling pathway, interleukin (IL)-17 signaling pathway and advanced glycosylation end product-the receptor of advanced glycosylation end product (AGE-RAGE) signaling pathway.
ConclusionsCurcumin may play an important role in the treatment of DR by regulating multiple signaling pathways to inhibit the inflammatory response and combat oxidative stress.
Key words:
Curcumin; Diabetic retinopathy; Network pharmacology; Genes
Contributor Information
Du Yuanyuan
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Wang Yiyun
Suzhou Medical College of Soochow University, Suzhou 215123, China
Zhao Rong
Suzhou Medical College of Soochow University, Suzhou 215123, China
Zhang Ji
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Ji Xiaoyan
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Lu Jiayu
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Ji Fangfang
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Lou Hui
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Jiang Ziyuan
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
Huang Jiang
Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China
